02:49 The most obvious mechanism by which increasing sugars might promote weight gain is by increasing energy consumption to an extent that exceeds energy output and distorts energy balance. For sugar sweetened beverages, it has been suggested that energy in liquid form could be less satiating than when derived from solid foods, resulting in increased consumption.104 Solid foods containing sugars are typically (although not invariably) energy dense, and frequent and substantial consumption of energy dense foods is associated with excessive weight gain and other measures of excess adiposity. We observed that isoenergetic replacement of dietary sugars with other macronutrients resulted in no change in weight (fig 5). This finding strongly suggested that energy imbalance is a major determinant of the potential for dietary sugars to influence measures of body fatness. However, other less direct mechanisms independent of energy balance have been proposed. 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